A BMW was stopped by Operation Fortitude officers at 5pm as it travelled from the Andover direction into Ludgershall.
Three occupants of the vehicle were searched and a large quantity of suspected class A drugs were located, as well as £1,000 cash and a knife.
A 16-year-old boy who had travelled from London was arrested and later charged with possession of a knife blade in a public place - he has been remanded in custody to appear at Swindon Magistrates Court this morning.
A 32-year-old man from Andover was arrested on suspicion of being concerned in the supply of class A drugs and driving whilst disqualified.
A 42-year-old man from Ludgershall was also arrested on suspicion of being concerned in the supply of class A drugs and possession of a knife blade in a public place. Both men have been interviewed and released under investigation while enquiries continue.
Det Con Mark Welch said: “These arrests and subsequent charge were conducted by officers from Operation Fortitude – our new proactive response unit – working closely with our colleagues in Hampshire Police.
"It is a good example of how county borders will not prevent us from tackling those intent on travelling into Wiltshire and causing harm.”